I started noticing visible signs of collagen loss in my late 20s, likely due to repeated exposure to formaldehyde and a course of broad-spectrum antibiotics (which are known to damage Type I collagen) a year or two earlier. These factors, combined with a lack of protective nutrients, likely accelerated the collagen loss, even at a young age.
Here’s what I wish I knew back then.
Collagen is a protein naturally produced in our bodies. It’s abundant in skin, hair, muscles, bones, tendons, ligaments, blood vessels, organs, and connective tissues. Collagen keeps the body strong by providing strength, structure, support and elasticity. However, collagen production begins to decline as early as our 20s, with a more noticeable decrease after age 40, leading to around 1% loss of collagen each year. By age 80, collagen production can be 75% lower than in young adults.
Historically, our diets likely provided more collagen and more variety of collagen types because people consumed more parts of animals and fish, such as skin, bones, and organ meats. Today, eating bone broth, fish skin or eating whole, small fish can help boost your dietary collagen intake.
Many studies have confirmed the benefits of collagen supplements, but with so many options available, it can be overwhelming to choose the right one. Here’s what you should consider:
As collagen supplements become more popular, it's important to be careful when choosing a product. Many collagen supplements on the market today are derived from animals raised on industrial factory farms, where they are exposed to heavy metals and toxic chemicals. These harmful substances accumulate in the soft tissues and bones—the very parts used to produce collagen.
In addition, many supplements are made from bovine hides that are treated with chemicals like sulfides and bleach to extract collagen peptides. Given these practices, it's not surprising that significant levels of arsenic, cadmium, and lead have been found in some popular collagen products, as highlighted by a report from the Clean Label Project.
Fish collagen should ideally be sourced from wild-caught fish, while bovine collagen is best when it comes from grass-fed or pasture-raised animals.
In addition to toxicity concerns, there have been reports of counterfeit supplements, especially on platforms like Amazon, where the ingredients or dosage do not match what's listed on the label. It’s best to choose brands that undergo third-party testing and purchase them directly from the manufacturer or official distributors like Fullscript who adhere to the manufacturer's recommendations for storage and shipping.
Maintaining a robust level of collagen in the body is clearly good for health. But are collagen supplements actually getting absorbed and used by the body? It seems so. A couple studies on hydrolyzed collagen have confirmed its absorption in the intestine and the subsequent rise of peptide levels (peak 1-4 hours later) in the blood.
Look for collagen supplements that are “hydrolyzed”, meaning the collagen is broken down into smaller protein chains called collagen peptides. This makes it easier for the body to absorb. Collagen supplementation can provide the building blocks for your body’s collagen production while also acting as a signal to stimulate the body to produce more collagen.
There are many different types of collagen, but Type I is the most abundant. Collagen supplements can come from many sources including bovine, marine, porcine, chicken, and eggshell. The majority of collagen supplements on the market contain a combination of collagen Type I and Type III from bovine sources.
Reviews on hydrolyzed collagen supplements show benefits to skin hydration, elasticity and reduction of wrinkle depth. Improvements in bone mineral density in women with osteopenia and osteoporosis have also been observed after 1 year of supplementation.
Studies on a specific type of hydrolyzed collagen (type I & III), have also shown improvements in joint mobility, joint pain and cartilage tissue including in knee osteoarthritis. The less common-type II collagen reduced pain in knee osteoarthritis better than glucosamine & chondroitin at 6 months time.
Marine collagen, primarily Type I collagen, is known for its faster absorption and quicker results, particularly when it comes to skin improvements, which can be seen in as little as 4 weeks. While it tends to be more expensive, it may be a better option for those specifically targeting skin, hair, and nail health. Sign in to see collagen products for skin.
For many people, high-quality bovine collagen is a cost-effective option that supports skin, hair, nails, joints, and bones, making it a versatile choice for overall health. While I recommend regularly eating a variety of collagen-rich foods, I prefer using researched collagen peptides when it comes to supplements for more consistent and predictable results. Some examples of patented collagen peptides include Fortigel, Fortibone, and Verisol. See products containing these peptides (sign in to see list).
Vegan Collagen? There are some products being developed using yeast but there is less known about these. There are, however, many vegan nutrients that can support collagen health like glycine and Vitamin C.
Collagen as source of protein While protein intake can stimulate insulin secretion to some extent, collagen is relatively low in the types of amino acids (like leucine) that are more likely to cause a significant insulin spike. Glycine, which is abundant in collagen, may even have a mild blood sugar-stabilizing effect. This means also means that although helpful for joints and mobility, collagen protein will not significantly contribute to building muscle mass.
Supplements are generally safe and well-tolerated, even with long-term use. Typical doses range from 2.5 to 15 grams per day. Collagen is most commonly taken as a powder (mixed in a beverage or smoothie), but also comes in capsule, liquid or gummy form.
Choosing the best collagen supplement for you depends on your health goals and dietary preferences or restrictions.
Taking collagen supplements is just one aspect of maintaining healthy collagen levels in your body. It's equally important to address factors that contribute to cellular toxicity - such as smoking, excessive alcohol consumption, sun exposure, blood sugar imbalances, lack of sleep, and environmental toxins - which can all accelerate collagen loss.
In addition, adequate protein intake and antioxidants like vitamins A, C, and E, along with selenium, zinc, and glutathione, can play a key role in supporting collagen health.
For skin health, I’ve also found photobiomodulation (PBM), or low-level light therapy, to be effective in enhancing hydration and elasticity. PBM stimulates fibroblasts to produce more collagen and boosts blood flow, aiding in skin repair and regeneration. Additionally, improvements in skin hydration and texture were observed following the fasting-mimicking diet.
While collagen supplements can help improve skin quality, strengthen joints, and support bone health, it's important to take a holistic approach. Addressing the various factors that contribute to collagen loss from multiple angles will provide the best short and long term support for maintaining healthy collagen levels.
References
Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016 Jan 29;15:14. doi: 10.1186/s12937-016-0130-8. PMID: 26822714
Campos LD, Santos Junior VA, Pimentel JD, Carregã GLF, Cazarin CBB. Collagen supplementation in skin and orthopedic diseases: A review of the literature. Heliyon. 2023 Mar 28;9(4):e14961. doi: 10.1016/j.heliyon.2023.e14961. PMID: 37064452
Luci C, Sibilla S. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018 Sep;57:97-108. doi: 10.1016/j.nutres.2018.06.001. Epub 2018 Jun 9. PMID: 30122200.
Hernández-Bule ML, Naharro-Rodríguez J, Bacci S, Fernández-Guarino M. Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation. Int J Mol Sci. 2024 Apr 19;25(8):4483. doi: 10.3390/ijms25084483. PMID: 38674067; PMCID: PMC11049838.
León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019 Nov 7;24(22):4031. doi: 10.3390/molecules24224031. PMID: 31703345; PMCID: PMC6891674.
Maloh J, Wei M, Hsu WC, Caputo S, Afzal N, Sivamani RK. The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial. J Clin Med. 2023 Feb 21;12(5):1710. doi: 10.3390/jcm12051710. PMID: 36902498; PMCID: PMC10003066.
Zhu C, Zhang W, Mu B, Zhang F, Lai N, Zhou J, Xu A, Liu J, Li Y. Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats. J Food Sci Technol. 2017 Jul;54(8):2260-2269. doi: 10.1007/s13197-017-2663-z. Epub 2017 Jun 14. PMID: 28740282; PMCID: PMC5502017.
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